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KMID : 0894520190230030231
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Development & Reproduction
2019 Volume.23 No. 3 p.231 ~ p.238
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Interleukin-8 (IL-8) Expression in the Olive Flounder (Paralichthys olivaceus) against Viral Hemorrhagic Septicemia Virus (VHSV) Challeng
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Kim Kyung-Hee
Kim Hyun-Chul
Park Choul-Ji
Park Jong-Won
Lee Young-Mee
Kim Woo-Jin
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Abstract
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Interleukin-8 (IL-8) is an inflammatory cytokine that plays an important role in the inflammatory response through the activation of neutrophil cells. The expression of IL-8 was investigated in early developmental stages of the olive flounder and in tissues of 8-month-old individuals. The expression of IL-8 increased after the initiation of the immune system rather than at the early stage of development, and high expression was observed in the gills and spleen, the organs associated with immunity and metabolism. In addition, IL-8 expression after infection by viral hemorrhagic septicemia virus significantly increased in the fin, gill, muscles, and spleen. These results suggest that IL-8 is closely related to inflammation and immune regulation in the immune response of the olive flounder and may be used as a basis for studies on the immune systems of other fish.
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KEYWORD
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Olive flounder Paralichthys olivaceus, Gene expression, Interleukin-8 (IL-8), Viral hemorrhagic septicemia virus (VHSV)
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